[HTML][HTML] An overview of mild traumatic brain injuries and emerging therapeutic targets

JP Bielanin, SAH Metwally, SS Paruchuri… - Neurochemistry …, 2024 - Elsevier
The majority of traumatic brain injuries (TBIs), approximately 90%, are classified as mild
(mTBIs). Globally, an estimated 4 million injuries occur each year from concussions or …

Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: Screening based on pharmacological and physiological properties

JD Pandya, S Musyaju, HR Modi… - Journal of Translational …, 2024 - Springer
Targeting drugs to the mitochondrial level shows great promise for acute and chronic
treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the …

Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice

Y Bai, K Li, X Li, X Chen, J Zheng, F Wu, J Chen… - Nature …, 2023 - nature.com
Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but
the mechanism remains unclear. GABAergic neurons in substantia nigra pars reticulata …

Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model

MI Hiskens, KM Li, AG Schneiders… - Frontiers in …, 2023 - frontiersin.org
Repetitive mild traumatic brain injuries (rmTBI) may contribute to the development of
neurodegenerative diseases through secondary injury pathways. Acetyl-L-carnitine (ALC) …

An update on essential micronutrients in critical illness

KWA Koekkoek, MM Berger - Current Opinion in Critical Care, 2023 - journals.lww.com
The needs in critical illness are higher than those of healthy individuals and must be
covered to support immunity. Monitoring selected micronutrients is justified in patients …

[HTML][HTML] Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

LA Sulaimon, LO Afolabi, RA Adisa… - Advances in Redox …, 2022 - Elsevier
The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal
cellular process. Besides ATP production, the mitochondria participate in various key …

[HTML][HTML] The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function

P Thapak, F Gomez-Pinilla - Pharmacological Research, 2024 - Elsevier
Mitochondria provide the energy to keep cells alive and functioning and they have the
capacity to influence highly complex molecular events. Mitochondria are essential to …

Chronic motor performance following different traumatic brain injury severity—A systematic review

F Corrigan, IC Wee, LE Collins-Praino - Frontiers in Neurology, 2023 - frontiersin.org
Introduction Traumatic brain injury (TBI) is now known to be a chronic disease, causing
ongoing neurodegeneration and linked to increased risk of neurodegenerative motor …

Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury

HR Modi, S Musyaju, M Ratcliffe, DA Shear… - Antioxidants, 2024 - mdpi.com
Traumatic brain injury (TBI) is a major global health problem that affects both civilian and
military populations worldwide. Post-injury acute, sub-acute, and chronic progression of …

High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury

S Ibeh, NMZ Bakkar, F Ahmad, J Nwaiwu, C Barsa… - Life Sciences, 2023 - Elsevier
Aims Traumatic brain injury (TBI) constitutes a serious public health concern. Although TBI
targets the brain, it can exert several systemic effects which can worsen the complications …