Highlights• We are only beginning to understand the mechanisms of active zone assembly.•
Trafficking, protein complex assembly, and membrane anchoring mechanisms are needed.• …

The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

Neuronal communication across synapses relies on neurotransmitter release from
presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic …

Neural circuit function depends on the pattern of synaptic connections between neurons and
the strength of those connections. Synaptic strength is determined by both postsynaptic …

Neurons communicate through neurotransmitter release at specialized synaptic regions
known as active zones (AZs). Using biosensors to visualize single synaptic vesicle fusion …

The gastropod mollusk Aplysia is an important model for cellular and molecular
neurobiological studies, particularly for investigations of molecular mechanisms of learning …

Neurons communicate through Ca2+-dependent neurotransmitter release at presynaptic
active zones (AZs). Neurotransmitter release properties play a key role in defining …

The kidneys generate about 180 l of primary urine per day by filtration of plasma. An
essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing …

Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their
release. In forward genetic screens, we isolated a novel Caenorhabditis elegans active zone …

At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors
activates retrograde signaling that precisely increases presynaptic neurotransmitter release …