Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Autophagy is a catabolic process in which cytoplasmic components are delivered to
vacuoles or lysosomes for degradation and nutrient recycling. Autophagy-mediated …

As a self‐degrading and highly conserved survival mechanism, autophagy plays an
important role in maintaining cell survival and recycling. The discovery of autophagy‐related …

Cholesterol is the most considerable member of a family of polycyclic compounds
understood as sterols, and represents an amphipathic molecule, such as phospholipids …

Niemann–Pick disease type C1 (NPC1) is a lysosomal lipid storage disease caused by
NPC1 gene mutation. Our previous study found that, compared with wild‐type (Npc1+/+) …

Abstract The Niemann-Pick type C1 (NPC1) protein is one of the key players of cholesterol
trafficking from the lysosome and its function is closely coupled with the Niemann-Pick type …

Niemann–Pick disease type C is a rare autosomal recessive of lysosomal storage disorder
characterized by impaired intracellular lipid transport and has a tendency to accumulate the …

Abstract Niemann–Pick type C (NPC), is a lysosomal storage disorder and belongs to a
group of diseases characterized by defective cholesterol trafficking. It is inherited with the …

Abstract Niemann-Pick Type C disease (NPC) is a fatal neurodegenerative lysosomal
storage disorder that primarily results from mutations in the late endosomal cholesterol …