Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Calcium-and integrin-binding protein 1 (CIB1) is a small, ubiquitously expressed protein that
was first identified as an intracellular binding partner of a platelet-specific α-integrin …

CD38 catalyzes the synthesis of the Ca2+ messenger, cyclic ADP-ribose (cADPR). It is
generally considered to be a type II protein with the catalytic domain facing outside. How it …

Pancreatic cancer cell invasion, metastasis, and angiogenesis are major challenges for the
development of novel therapeutic strategies. Protein kinase D (PKD) isoforms are involved …

Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which, despite
combined modality treatment, reoccurs and is invariably fatal for affected patients. Recently …

Protein ubiquitylation is an important post-translational modification, regulating aspects of
virtually every biochemical pathway in eukaryotic cells. Hundreds of enzymes participate in …

Most gastrointestinal stromal tumors (GISTs) develop due to gain-of-function mutations in the
tyrosine kinase gene, KIT. We recently showed that mutant KIT mislocalizes to the Golgi area …

CIB1 (calcium and integrin binding protein 1) is a small intracellular protein with numerous
interacting partners, and hence has been implicated in various cellular functions. Recent …

Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which
is involved in many cellular processes, including calcium signaling, cell survival and …

Abstract Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD
family of calcium–calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and …