HSV-1 cytoplasmic envelopment and egress
I Ahmad, DW Wilson - International journal of molecular sciences, 2020 - mdpi.com
Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …
Viral cell-to-cell spread: Conventional and non-conventional ways
N Cifuentes-Munoz, F El Najjar, RE Dutch - Advances in virus research, 2020 - Elsevier
A critical step in the life cycle of a virus is spread to a new target cell, which generally
involves the release of new viral particles from the infected cell which can then initiate …
involves the release of new viral particles from the infected cell which can then initiate …
Function of glycoprotein E of herpes simplex virus requires coordinated assembly of three tegument proteins on its cytoplasmic tail
Glycoprotein E (gE) of HSV plays a key role in cell-to-cell spread and virus-induced cell
fusion. Here, we report that this function of gE requires the cooperation of tegument proteins …
fusion. Here, we report that this function of gE requires the cooperation of tegument proteins …
The challenge of developing a herpes simplex virus 2 vaccine
LK Dropulic, JI Cohen - Expert review of vaccines, 2012 - Taylor & Francis
HSV infections are prevalent worldwide. A vaccine to prevent genital herpes would have a
significant impact on this disease. Several vaccines have shown promise in animal models; …
significant impact on this disease. Several vaccines have shown promise in animal models; …
Herpes simplex virus dances with amyloid precursor protein while exiting the cell
Herpes simplex type 1 (HSV1) replicates in epithelial cells and secondarily enters local
sensory neuronal processes, traveling retrograde to the neuronal nucleus to enter latency …
sensory neuronal processes, traveling retrograde to the neuronal nucleus to enter latency …
Current status and prospects for development of an HSV vaccine
Herpes simplex virus type 2 (HSV-2) infects 530 million people, is the leading cause of
genital ulcer disease, and increases the risk of HIV-1 acquisition. Although several …
genital ulcer disease, and increases the risk of HIV-1 acquisition. Although several …
The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B
JC Carmichael, H Yokota, RC Craven, A Schmitt… - PLoS …, 2018 - journals.plos.org
All herpesviruses have mechanisms for passing through cell junctions, which exclude
neutralizing antibodies and offer a clear path to neighboring, uninfected cells. In the case of …
neutralizing antibodies and offer a clear path to neighboring, uninfected cells. In the case of …
Replication of herpes simplex virus: egress of progeny virus at specialized cell membrane sites
In the final stages of the herpes simplex virus 1 (HSV-1) life cycle, a viral nucleocapsid buds
into a vesicle of trans-Golgi network (TGN)/endosome origin, acquiring an envelope and an …
into a vesicle of trans-Golgi network (TGN)/endosome origin, acquiring an envelope and an …
Blocking herpes simplex virus 2 glycoprotein E immune evasion as an approach to enhance efficacy of a trivalent subunit antigen vaccine for genital herpes
S Awasthi, J Huang, C Shaw, HM Friedman - Journal of virology, 2014 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 2 (HSV-2) subunit antigen vaccines targeting virus entry
molecules have failed to prevent genital herpes in human trials. Our approach is to include a …
molecules have failed to prevent genital herpes in human trials. Our approach is to include a …
Herpes simplex virus gE/gI and US9 promote both envelopment and sorting of virus particles in the cytoplasm of neurons, two processes that precede anterograde …
Herpes simplex virus (HSV) anterograde transport in neuronal axons is vital, allowing
spread from latently infected ganglia to epithelial tissues, where viral progeny are produced …
spread from latently infected ganglia to epithelial tissues, where viral progeny are produced …