Human haematopoietic stem cell development: from the embryo to the dish

A Ivanovs, S Rybtsov, ES Ng, EG Stanley… - …, 2017 - journals.biologists.com
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

Understanding the journey of human hematopoietic stem cell development

A Kumar, SS D'Souza, AS Thakur - Stem cells international, 2019 - Wiley Online Library
Hematopoietic stem cells (HSCs) surface during embryogenesis leading to the genesis of
the hematopoietic system, which is vital for immune function, homeostasis balance, and …

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

GI Uenishi, HS Jung, A Kumar, MA Park… - Nature …, 2018 - nature.com
NOTCH signaling is required for the arterial specification and formation of hematopoietic
stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad …

Generation of CD34 fluorescent reporter human induced pluripotent stem cells for monitoring hematopoietic differentiation

AM Husa, MR Strobl, A Strajeriu, M Wieser… - Stem Cells and …, 2018 - liebertpub.com
Hematopoietic stem and progenitor cells (HSPCs) derived from human induced pluripotent
stem cells (hiPSCs) hold great promise for disease modeling, drug screens, and eventually …

Generation of T cells from human and nonhuman primate pluripotent stem cells

A Kumar, SS D'Souza, G Uenishi, MA Park, JH Lee… - Bio …, 2020 - bio-protocol.org
Pluripotent stem cells (PSCs) have the potential to provide homogeneous cell populations of
T cells that can be grown at a clinical scale and genetically engineered to meet specific …

Assessment of Endothelial-to-Hematopoietic Transition of Individual Hemogenic Endothelium and Bulk Populations in Defined Conditions

GI Uenishi, HS Jung, II Slukvin - Stem Cell Assays: Methods and Protocols, 2022 - Springer
Endothelial-to-hematopoietic transition (EHT) is a unique morphogenic event in which flat,
adherent hemogenic endothelial (HE) cells acquire round, non-adherent blood cell …

Recapitulating Hematopoietic Development in a Dish

K Vanuytsel, MH Steinberg, GJ Murphy - … of iPS Cells: Innovation in Medical …, 2019 - Springer
The ability to generate patient-specific, induced pluripotent stem cells (iPSCs) together with
the advent of gene-editing technologies has opened up a realm of opportunities for disease …

Generation of Pecam1 endothelial specific dual reporter mouse model

D Hu, L Zhang, F Yang, F Chen, D Li, CL Cai - genesis, 2020 - Wiley Online Library
Endothelial cells are specialized epithelium lining the interior surface of vessels and play
fundamental roles in angiogenesis, vascular permeability, and immune response. To identify …

Method for the Induction of Arterial-Type of Hemogenic Endothelium from hPSCS

II Slukvin, G Uenishi - US Patent App. 17/233,643, 2021 - Google Patents
US20210261923A1 - Method for the Induction of Arterial-Type of Hemogenic Endothelium from
hPSCS - Google Patents US20210261923A1 - Method for the Induction of Arterial-Type of …

Method for the induction of arterial-type of hemogenic endothelium from hPSCS

II Slukvin, G Uenishi - US Patent 10,982,192, 2021 - Google Patents
This invention discloses a method for the induction of arterial-type of hemogenic
endothelium. Aylon (Leukemia, 29: 1741-1753, 2015)(Year: 2015).* Boiers (Cell Stem Cell …