Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Early-onset colorectal cancer (EOCRC), defined as that diagnosed before the age of 50,
accounts for 10–12% of all new colorectal cancer (CRC) diagnoses. Epidemiological data …

Hereditary cancer syndromes account for nearly 10% of cancers even though they are often
underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in …

This review of the familial tumor syndromes involving the endocrine organs is focused on
discussing the main updates on the upcoming fifth edition of the WHO Classification of …

Ampullary carcinomas (ACs) represent a rare entity, accounting for approximately 0.2% of all
gastrointestinal solid tumors and 20% of all periampullary cancers (PACs). Unfortunately …

Colorectal cancer is one of the most common tumors, and genetic predisposition is one of
the key risk factors in the development of this malignancy. Lynch syndrome and familial …

Simple Summary In this review, the authors will discuss the highlights of early onset colon
cancer (EOCRC), an increasing but still unclear phenomenon. Indeed, the risk factors are …

Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer death
worldwide; most of cases are sporadic, however about 5% to 10% report a hereditary …

Familial adenomatous polyposis (FAP) is a genetic syndrome characterized by the presence
of multiple polyps in the gastrointestinal tract and a wide range of systemic extra-intestinal …

Simple Summary This review article is a summary of the current state of knowledge
regarding the genetics of pancreatic cancer and a presentation of possible treatment options …