Purpose Within this study, we aimed to discover novel gene–disease associations in
patients with no genetic diagnosis after exome/genome sequencing (ES/GS). Methods We …

Alternative splicing is a crucial regulator in stem cell biology, intricately influencing the
functions of various biological macromolecules, particularly pre-mRNAs and the resultant …

Development is a highly controlled process of cell proliferation and differentiation driven by
mechanisms of dynamic gene regulation. Specific DNA binding factors for establishing cell …

TATA‐binding protein associated factor 4 (TAF4) is a subunit of the Transcription Factor IID
(TFIID) complex, a central player in transcription initiation. Other members of this multimeric …

Reprogramming of somatic cells has become a versatile tool for biomedical research and for
regenerative medicine. In the current study, we show that manipulating alternative splicing …

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease that is
widely associated with Grey and white matter degradation due to the demyelination of …

Regulatory transcription factors interact with the basic transcriptional machinery to initiate
genetranscription. In contrast to regulatory factors, the basic transcriptional machinery has …