Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

Background Aging is a significant risk factor for ischemic stroke and worsens its outcome.
However, the mechanisms for this worsened neurological outcome with aging are not clearly …

Abstract Semaphorin 3A (Sema3A) increased significantly in mouse brain following cerebral
ischemia. However, the role of Sema3A in stroke brain remains unknown. Our aim was to …

Cerebral vasogenic edema, a severe complication of ischemic stroke, aggravates
neurological deficits. However, therapeutics to reduce cerebral edema still represent a …

Background Promotion of functional recovery in patients is the primary goal of stroke
management. However, its achievement is low due to the lack of full understanding of the …

Withania somnifera (WS), popularly known as “Ashwagandha” has been used for centuries
as a nerve tonic. Its protective effect has been elucidated in many neurodegenerative …

Prolonged occlusion of multiple microvessels causes microvascular injury. G protein-
coupled receptor 124 (GPR124) has been reported to be required for maintaining central …

Background Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which
neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix …

В научном обзоре обосновывается роль лейкоцитов и микроглии в патогенезе
воспаления ишемизированного мозга. Первоначальное повреждение нейронов …

The scientific review substantiates the role of leukocytes and microglia in the pathogenesis
of inflammation in the ischemic brain. Initial neuronal damage occurs within minutes of …