Antiepileptogenic, antioxidant and genotoxic evaluation of rosmarinic acid and its metabolite caffeic acid in mice

VR Coelho, CG Vieira, LP de Souza, F Moysés… - Life Sciences, 2015 - Elsevier
Aims Antioxidant compounds have been extensively investigated as a pharmacological
alternatives to prevent epileptogenesis. Rosmarinic acid (RA) and caffeic acid (CA) are …

Central histaminergic signalling, neural excitability and epilepsy

L Yang, Y Wang, Z Chen - British Journal of Pharmacology, 2022 - Wiley Online Library
Epilepsy is a common neurological disorder characterized by repeated and spontaneous
epileptic seizures and is not well controlled by current medication. Traditional theory …

Effect of Anacyclus pyrethrum on Pentylenetetrazole-Induced Kindling, Spatial Memory, Oxidative Stress and Rho-Kinase II Expression in Mice

M Pahuja, J Mehla, KH Reeta, M Tripathi… - Neurochemical …, 2013 - Springer
Anacyclus pyrethrum (A. pyrethrum) has been reported to exhibit anticonvulsant activity. In
the present study, the effect of hydro-alcoholic extract of A. pyrethrum root (HEAP) on …

Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats

S Tahmasebi, S Oryan, HR Mohajerani, N Akbari… - Epilepsy & Behavior, 2020 - Elsevier
Introduction Epilepsy is a most common neurological disorder that has negative effects on
cognition. In the present study, we investigated the protective effect of Nigella sativa (NS) …

Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy

R Tambe, A Patil, P Jain, J Sancheti… - Pharmaceutical …, 2017 - Taylor & Francis
Abstract Context: Eclipta alba (Linn) Hassk.(Asteraceae) has been reported to be a nerve
tonic and has been used to treat epilepsy in folk medicine. Objective: The present study …

Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF‐κB Pathway

L Wu, Z Ye, Z Zhuang, Y Gao, C Tang… - Behavioural …, 2018 - Wiley Online Library
Inflammatory injury and neuronal apoptosis participate in the period of early brain injury
(EBI) after subarachnoid hemorrhage (SAH). Suppression of inflammation has recently been …

Prenatal stress alters microglial development and distribution in postnatal rat brain

B Gómez-González, A Escobar - Acta neuropathologica, 2010 - Springer
Stress affects microglial function and viability during adulthood and early postnatal life;
however, it is unknown whether stress to the pregnant dam might alter offspring microglia …

Betahistine attenuates seizures, neurodegeneration, apoptosis, and gliosis in the cerebral cortex and hippocampus in a mouse model of epilepsy: A histological …

AM Shalaby, HEM Sharaf Eldin… - Microscopy and …, 2022 - academic.oup.com
Epilepsy is a prevalent and chronic neurological disorder marked by recurring,
uncontrollable seizures of the brain. Chronic or repeated seizures produce memory …

Roles of pannexin-1 channels in inflammatory response through the TLRs/NF-kappa B signaling pathway following experimental subarachnoid hemorrhage in rats

LY Wu, ZN Ye, CH Zhou, CX Wang, GB Xie… - Frontiers in Molecular …, 2017 - frontiersin.org
Background: Accumulating evidence suggests that neuroinflammation plays a critical role in
early brain injury after subarachnoid hemorrhage (SAH). Pannexin-1 channels, as a …

The effects of aqueous extract of Boswellia Serrata on hippocampal region CA1 and learning deficit in kindled rats

C Jalili, MR Salahshoor, A Pourmotabbed… - Research in …, 2014 - journals.lww.com
Temporal lobe epilepsy (TLE) is a disorder of the central nervous system in which
hippocampus is mostly involved and causes memory impairment. Kindling is a model of …