High-throughput tools for nucleic acid characterization now provide the means to conduct
comprehensive analyses of all somatic alterations in the cancer genomes. Both large-scale …

Vaccination has played a significant role in controlling and eliminating life-threatening
infectious diseases throughout the world, and yet currently licensed vaccines represent only …

As larger‐scale cloning projects become more prevalent, there is an increasing need for
comparisons among high fidelity DNA polymerases used for PCR amplification. All …

The bacterial second messenger cyclic di-GMP (c-di-GMP) controls biofilm formation and
other phenotypes relevant to pathogenesis. Cyclic-di-GMP is synthesized by diguanylate …

Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a
variety of complex processes through a diverse set of c-di-GMP receptor proteins. We have …

It can be argued that the arrival of the “genomics era” has significantly shifted the paradigm
of vaccine and therapeutics development from microbiological to sequence-based …

Protein microarrays are versatile tools for parallel, miniaturized screening of binding events
involving large numbers of immobilized proteins in a time-and cost-effective manner. They …

We report a method for high-throughput, cost-efficient empirical discovery of optimal
proteotypic peptides and fragment ions for targeted proteomics applications using in vitro …

The comprehensive study of protein structure and function, or proteomics, depends on the
obtainability of full‐length cDNAs in species‐specific expression vectors and subsequent …

Protein production is one of the key steps in biotechnology and functional proteomics.
Expression of proteins in heterologous hosts (such as in E. coli) is generally lengthy and …