Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune
disorder which affects small-and, to a lesser degree, medium-sized vessels. ANCA …

▪ Abstract The immune response is regulated not only by cell proliferation and differentiation,
but also by programmed cell death, or apoptosis. In response to various stimuli, death …

Interactions between the immune system and malignant cells play an important role in
tumorigenesis. Failure of the immune system to detect and reject transformed cells may lead …

The mammalian airway is lined by a variety of specialized epithelial cells that not only serve
as a physical barrier but also respond to environment-induced damage through the release …

Abstract Preformed Fas ligand (FasL) and APO2 ligand (APO2L)/TNF-related apoptosis-
inducing ligand (TRAIL) are stored in the cytoplasm of the human Jurkat T cell line and of …

Immunotherapy based on checkpoint inhibitors is providing substantial clinical benefit, but
only to a minority of cancer patients. The current priority is to understand why the majority of …

Apoptosis, also known as programmed cell death, is the major type of cell death involved in
normal development, regeneration, proliferation and pathologic degeneration in the central …

Activation of the Fas/FasL system induces apoptosis of susceptible cells, but may also lead
to nuclear factor κB activation. Our goal was to determine whether local Fas activation …

Tolerance to the foetal 'allograft'has been extensively studied in the past few years,
providing interesting new insights. In addition to a potential role for HLA-G, which has been …

Fas ligand (FasL) has been shown to mediate both apoptotic and inflammatory reactions. To
rigorously assess the physiological role of different forms of the FasL molecule with regard to …