Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Chemically modified platforms for better RNA therapeutics

Y Shi, X Zhen, Y Zhang, Y Li, S Koo, Q Saiding… - Chemical …, 2024 - ACS Publications
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Functional DNA–polymer conjugates

CJ Whitfield, M Zhang, P Winterwerber, Y Wu… - Chemical …, 2021 - ACS Publications
DNA nanotechnology has seen large developments over the last 30 years through the
combination of solid phase synthesis and the discovery of DNA nanostructures. Solid phase …

[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials

C Chen, DYW Ng, T Weil - Progress in Polymer Science, 2020 - Elsevier
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …

A crosslinked nucleic acid nanogel for effective siRNA delivery and antitumor therapy

F Ding, Q Mou, Y Ma, G Pan, Y Guo… - Angewandte Chemie …, 2018 - Wiley Online Library
Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐
grafted polycaprolactone (DNA‐g‐PCL) brushes to form spherical and nanosized hydrogels …

Hydrophobic interaction: a promising driving force for the biomedical applications of nucleic acids

F Xiao, Z Chen, Z Wei, L Tian - Advanced Science, 2020 - Wiley Online Library
The comprehensive understanding and proper use of supramolecular interactions have
become critical for the development of functional materials, and so is the biomedical …

Inspired Beyond Nature: Three Decades of Spherical Nucleic Acids and Colloidal Crystal Engineering with DNA

CA Mirkin, SH Petrosko - 2023 - ACS Publications
The conception, synthesis, and invention of a nanostructure, now known as the spherical
nucleic acid, or SNA, in 1996 marked the advent of a new field of chemistry. Over the past …

[HTML][HTML] Delivery of therapeutic oligonucleotides in nanoscale

L Wu, W Zhou, L Lin, A Chen, J Feng, X Qu, H Zhang… - Bioactive materials, 2022 - Elsevier
Therapeutic oligonucleotides (TOs) represent one of the most promising drug candidates in
the targeted cancer treatment due to their high specificity and capability of modulating …

Expanding the architectural horizon of nucleic-acid-polymer biohybrids by site-controlled incorporation of ATRP initiators in DNA and RNA

J Jeong, G Szczepaniak, SR Das, K Matyjaszewski - Chem, 2023 - cell.com
Modifying biomacromolecules with synthetic polymers has been a powerful approach to
developing multifunctional hybrid biomaterials for nanoscience and biomedical applications …