All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

In cancer, the tumour suppressor gene TP53 undergoes frequent missense mutations that
endow mutant p53 proteins with oncogenic properties. Until now, a universal mutant p53 …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

BACKGROUND Systemic sclerosis (SSc) is an autoimmune, connective tissue disease
characterized by vasculopathy and fibrosis of the skin and internal organs. METHODS We …

Proteasome is the principal hydrolytic machinery responsible for the great majority of protein
degradation. The past three decades have testified prominent advances about proteasome …

While autophagy is thought to be an essential process in some cancer cells, it is unknown if
or how such cancer cells can circumvent autophagy inhibition. To address this, we …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and,
when combined, can result in potent inhibition of cancer growth. Combination therapies can …

Severe COVID-19 disease leads to hypoxemia, inflammation and lymphopenia. Viral
infection induces cellular stress and causes the activation of the innate immune response …