How disease-associated mutations impair protein activities in the context of biological
networks remains mostly undetermined. Although a few renowned alleles are well …

Context Chronic inflammation of the prostate has been associated with preneoplastic
lesions and cancer development. Multiple causes have been considered for chronic …

Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene
expression comparisons utilize full-thickness biopsies, with substantial amount of dermis …

Psoriasis is a chronic autoimmune human skin disorder that is characterized by excessive
proliferation of keratinocytes, scaly plaques, severe inflammation and erythema. The …

Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait.
Although genome-wide association scans (GWAS) have identified 36 disease susceptibility …

ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …

Psoriasis vulgaris (PsV) is a common, chronic skin disease with a complex genetic and
environmental etiology. We investigated, in 461 psoriatic patients and 454 healthy controls …

It has been shown that inter-individual variation in host response to porcine reproductive
and respiratory syndrome (PRRS) has a heritable component, yet little is known about the …

Glucocorticoids have multiple therapeutic benefits and are used both for
immunosuppression and treatment purposes. Notwithstanding their benefits, glucocorticoid …

Background The centrosome is one of the most important non-membranous organelles
regulating microtubule organization and progression of cell mitosis. The coiled-coil alpha …