Time of sample collection is critical for the replicability of microbiome analyses

C Allaband, A Lingaraju, S Flores Ramos, T Kumar… - Nature …, 2024 - nature.com
As the microbiome field moves from descriptive and associative research to mechanistic and
interventional studies, being able to account for all confounding variables in the …

Through an animal's eye: the implications of diverse sensory systems in scientific experimentation

JS Brebner, M Loconsole… - Proceedings of the …, 2024 - royalsocietypublishing.org
'Accounting for the sensory abilities of animals is critical in experimental design.'No
researcher would disagree with this statement, yet it is often the case that we inadvertently …

Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research

RJ Lucas, AE Allen, GC Brainard, TM Brown… - PLoS …, 2024 - journals.plos.org
Light enables vision and exerts widespread effects on physiology and behavior, including
regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive …

Researchers need to better address time-of-day as a critical biological variable

RJ Nelson, AC DeVries, BJ Prendergast - Proceedings of the National …, 2024 - pnas.org
Nearly all physiological and behavioral processes display daily rhythms driven by
endogenous circadian clocks—molecular representations of the external solar day …

Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism

SK Munyoki, JP Goff, A Kolobaric, A Long, SJ Mullett… - Iscience, 2023 - cell.com
Circadian rhythms dynamically regulate sex differences in metabolism and immunity, and
circadian disruption increases the risk of metabolic disorders. We investigated the role of sex …

Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery

M Weger, BD Weger, F Gachon - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Introduction Most mammalian physiology is orchestrated by the circadian clock, including
drug transport and metabolism. As a result, efficacy and toxicity of many drugs are …

Occupational exposure to electromagnetic fields—different from general public exposure and laboratory studies

K Hansson Mild, MO Mattsson, P Jeschke… - International Journal of …, 2023 - mdpi.com
The designs of in vivo, in vitro and in silico studies do not adequately reflect the
characteristics of long-term occupational EMF exposure; the higher exposure levels …

[HTML][HTML] Nonalcoholic steatohepatitis disrupts diurnal liver transcriptome rhythms in mice

LVM de Assis, M Demir, H Oster - Cellular and Molecular Gastroenterology …, 2023 - Elsevier
Background & Aims The liver ensures organismal homeostasis through modulation of
physiological functions over the course of the day. How liver diseases such as nonalcoholic …

Beyond Lux: methods for species and photoreceptor-specific quantification of ambient light for mammals

RJ McDowell, A Didikoglu, T Woelders, MJ Gatt… - BMC biology, 2024 - Springer
Background Light is a key environmental regulator of physiology and behaviour. Mistimed or
insufficient light disrupts circadian rhythms and is associated with impaired health and well …

Taking biological rhythms into account: From study design to results reporting

MAB Oliveira, ACOV de Abreu, DB Constantino… - Physiology & …, 2024 - Elsevier
Numerous physiological and behavioral processes in living organisms exhibit strong
rhythmicity and are regulated within a 24-hour cycle. These include locomotor activity and …