The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Cellular senescence constitutes a stress response mechanism in reaction to a plethora of
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …

Abstract BCL-X L and BCL-2 are key anti-apoptotic proteins and validated cancer targets.
753B is a novel BCL-X L/BCL-2 proteolysis targeting chimera (PROTAC) that targets both …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Background The microvascular endothelium inherently controls nutrient delivery, oxygen
supply, and immune surveillance of malignant tumors, thus representing both biological …

High-grade gliomas are primary brain tumors that are incredibly refractory long-term to
surgery and chemoradiation, with no proven durable salvage therapies for patients that have …

Abstract Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells.
The associated cytostasis has been shown to be reversible and cells escaping senescence …

Bladder cancer (BCa) is the 10th most commonly diagnosed cancer worldwide, and cellular
senescence is defined as a state of permanent cell cycle arrest and considered to play …

Therapy-induced senescence (TIS) is a state of stable proliferative arrest of both normal and
neoplastic cells that is triggered by exposure to anticancer treatments. TIS cells acquire a …

Pancreatic Ductal Adenocarcinoma (PDAC) is projected to become the 2nd leading cause of
cancer-related deaths in the United States. Limitations in early detection and treatment …