The incidence of gallstone disease has increased in recent years. The pathogenesis of
cholelithiasis is not fully understood. The occurrence of the disease is influenced by both …

The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …

Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent
hypoglycaemia in infants and young children caused by inappropriate insulin over …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

Background: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin
secretion is the most common and most severe cause of persistent hypoglycemia in infants …

Background Up to now, only limited data on long-term medical treatment in congenital
hyperinsulinism (CHI) is available. Moreover, most of the drugs used in CHI are therefore not …

Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis
and treatment, it was considered necessary to formulate evidence-based clinical practice …

Background Congenital chylothorax (CCT) is a rare disease of unknown aetiology.
Treatment approaches vary; none has been evaluated prospectively. Objective To …

Background Octreotide is a synthetic peptide analog of naturally occurring somatostatin.
Octreotide is used off‐label in children< 6 years of age for hyperinsulinism, chylothorax, and …