Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Simulation studies of amyloidogenic polypeptides and their aggregates

IM Ilie, A Caflisch - Chemical reviews, 2019 - ACS Publications
Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …

Effects of electric fields and electromagnetic wave on food protein structure and functionality: A review

Z Han, M Cai, JH Cheng, DW Sun - Trends in food science & technology, 2018 - Elsevier
Background Protein is an essential component of human diet and can be applied to many
aspects in food systems due to its abundant nutritional value and functional properties …

Enhancing the biological activities of food protein-derived peptides using non-thermal technologies: a review

GJ Fadimu, TT Le, H Gill, A Farahnaky, OO Olatunde… - Foods, 2022 - mdpi.com
Bioactive peptides (BPs) derived from animal and plant proteins are important food
functional ingredients with many promising health-promoting properties. In the food industry …

Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: from scattering and spectroscopy to nanoindentation and nanodevices

R Di Santo, S Romanò, A Mazzini, S Jovanović… - Nanomaterials, 2021 - mdpi.com
Exosomes (EXOs) are nano-sized vesicles secreted by most cell types. They are abundant
in bio-fluids and harbor specific molecular constituents from their parental cells. Due to these …

The biophysics of disordered proteins from the point of view of single-molecule fluorescence spectroscopy

J Cubuk, MD Stuchell-Brereton… - Essays in …, 2022 - portlandpress.com
Intrinsically disordered proteins (IDPs) and regions (IDRs) have emerged as key players
across many biological functions and diseases. Differently from structured proteins …

Disordered proteins mitigate the temperature dependence of site-specific binding free energies

JF Thole, CA Waudby, GJ Pielak - Journal of Biological Chemistry, 2023 - ASBMB
Biophysical characterization of protein–protein interactions involving disordered proteins is
challenging. A common simplification is to measure the thermodynamics and kinetics of …

Molecular dynamics simulations combined with nuclear magnetic resonance and/or small-angle X-ray scattering data for characterizing intrinsically disordered protein …

M Chan-Yao-Chong, D Durand… - Journal of Chemical …, 2019 - ACS Publications
The concept of intrinsically disordered proteins (IDPs) has emerged relatively slowly, but
over the past 20 years, it has become an intense research area in structural biology. Indeed …

Modeling Solution Behavior of Poly(N-isopropylacrylamide): A Comparison between Water Models

L Tavagnacco, E Zaccarelli… - The Journal of Physical …, 2022 - ACS Publications
Water is known to play a fundamental role in determining the structure and functionality of
macromolecules. The same crucial contribution is also found in the in silico description of …

Mechanistic insights into the changes of enzyme activity in food processing under microwave irradiation

H Cao, X Wang, J Liu, Z Sun, Z Yu… - … Reviews in Food …, 2023 - Wiley Online Library
Microwave (MW) and enzyme catalysis are two emerging processing tools in the field of food
industry. Recently, MW has been widely utilized as a novel type of green and safe heating …