Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

▪ Abstract Fragile X syndrome is one of the most common forms of inherited mental
retardation. In most cases the disease is caused by the methylation-induced transcriptional …

More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …

Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common
cause of inherited intellectual disability, yet it is unknown how FMRP function varies across …

Absence of functional FMRP causes Fragile X syndrome. Abnormalities in synaptic
processes in the cerebral cortex and hippocampus contribute to cognitive deficits in Fragile …

Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting
cognitive and behavioral function in humans. This syndrome is characterized by a cluster of …

Deficiency in fragile X mental retardation protein (FMRP) results in fragile X syndrome (FXS),
an inherited form of intellectual disability. Despite extensive research, it is unclear how …

Trace fear memory requires the activity of the anterior cingulate cortex (ACC) and is
sensitive to attention-distracting stimuli. Fragile X syndrome is the most common form of …

A long-standing relationship between nicotinic acetylcholine receptors (nAChRs) and
cognition exists. Drugs that act at nAChRs can have cognitive-enhancing effects and …

The FMR1 gene, mutated in Fragile X syndrome patients, has been modeled in mice with a
neomycin cassette inserted in exon 5 of the mouse Fmr1 gene creating an Fmr1 knockout …