Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Pericytes play a key role in the development of cerebral microcirculation. The exact role of
pericytes in the neurovascular unit in the adult brain and during brain aging remains …

A recent explosion in newly discovered vascular growth factors has coincided with
exploitation of powerful new genetic approaches for studying vascular development. An …

The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires
recruitment of mural cells, generation of an extracellular matrix and specialization of the …

Blood vessels are composed of two interacting cell types. Endothelial cells form the inner
lining of the vessel wall, and perivascular cells—referred to as pericytes, vascular smooth …

Development of a vascular system involves the assembly of two principal cell types–
endothelial cells and vascular smooth muscle cells/pericytes (vSMC/PC)–into many different …

Tissue engineering has been an active field of research for several decades now. However,
the amount of clinical applications in the field of tissue engineering is still limited. One of the …

Mural cells are essential components of blood vessels and are necessary for normal
development, homeostasis, and organ function. Alterations in mural cell density or the stable …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …