Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

Pattern recognition receptors (PRRs) expressed on immune cells are crucial for the early
detection of invading pathogens, in initiating early innate immune response and in …

Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of CD5+
CD23+ B cells in blood, marrow, and second lymphoid tissues. Gene-expression profiling …

Chronic lymphocytic leukemia (CLL) can be immunosuppressive in humans and mice, and
CLL cells share multiple phenotypic markers with regulatory B cells that are competent to …

Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western
world. Despite the positive clinical effects of new targeted therapies, CLL still remains an …

Targeted therapy is revolutionizing the treatment of cancers, but resistance evolves against
these therapies and derogates their success. The phosphatidylinositol 3-kinase delta (PI3K …

Leukemia is a cancer of the white blood cells, with over 54,000 new cases per year
diagnosed worldwide and a 5-year survival rate below 60%. This highlights a need for …

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen found
on chronic lymphocytic leukemia (CLL) B cells, but not on normal adult tissues. We …

Mouse models that recapitulate human malignancy are valuable tools for the elucidation of
the underlying pathogenetic mechanisms and for preclinical studies. Several genetically …

Chronic lymphocytic leukemia (CLL) cells require complex microenvironmental and
immunologic interactions to survive and proliferate. Such interactions might be best …