Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Emerging therapeutic treatments based on the production of proteins by delivering mRNA
have become increasingly important in recent times. While lipid nanoparticles (LNPs) are …

A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

CRISPR‐based genome editing technology has become an important potential therapeutic
tool for various diseases. A vital challenge is to reach a safe, efficient, and clinically suitable …

Successful cytosolic delivery of nanomaterials is becoming more and more important, given
the increase in intracellular applications of quantum dots, gold nanoparticles, liposomal drug …

Active targeting that exploits the (over) expression of surface receptors in target cells by
ligand incorporation is a central concept in nanomedicine research. Despite unprecedented …

Nanotechnology-based gene delivery is the division of nanomedicine concerned with the
synthesis, characterization, and functionalization of nanomaterials to be used in targeted …

Abstract mRNA‐based therapeutics are a unique class of drugs for treatment of human
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …

Liposomes, vesicles composed of a phospholipid bilayer, are considered a remarkably
advanced drug delivery system due to their unique properties, including their …