Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

This article reviews the literature regarding the structure and function of two types of
exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) …

Phenol-soluble modulins (PSMs) are a recently discovered family of amphipathic, alpha-
helical peptides that have multiple roles in staphylococcal pathogenesis and contribute to a …

Atopic dermatitis (AD) is a common skin disease that affects a large proportion of the
population worldwide. The incidence of AD has increased over the last several decades …

One key aspect of the virulence of Staphylococcus aureus lies in its ability to target the host
cell membrane with a large number of membrane-damaging toxins and peptides. In this …

Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of
niches in its human host. Aside from the classical manifestations of S. aureus-induced …

Abstract α-Hemolysin of Staphylococcus aureus is a self-assembling toxin that forms a water-
filled transmembrane channel upon oligomerization in a lipid membrane. Apart from being …

We report that the introduction of low concentrations of intracellular trehalose can greatly
improve the survival of mammalian cells during cryopreservation. Using a genetically …

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections
are predominantly those affecting skin and soft tissues. Although progress has been made …