Synopsis of guidelines for the clinical management of cerebral cavernous malformations: consensus recommendations based on systematic literature review by the …

A Akers, RAS Salman, IA Awad, K Dahlem… - …, 2017 - journals.lww.com
BACKGROUND: Despite many publications about cerebral cavernous malformations
(CCMs), controversy remains regarding diagnostic and management strategies …

Childhood stroke

PB Sporns, HJ Fullerton, S Lee, H Kim, WD Lo… - Nature Reviews …, 2022 - nature.com
Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation

J Weng, Y Yang, D Song, R Huo, H Li, Y Chen… - The American Journal of …, 2021 - cell.com
Cerebral cavernous malformations (CCMs) are vascular disorders that affect up to 0.5% of
the total population. About 20% of CCMs are inherited because of familial mutations in CCM …

Natural history of cavernous malformation: systematic review and meta-analysis of 25 studies

S Taslimi, A Modabbernia, S Amin-Hanjani, FG Barker… - Neurology, 2016 - AAN Enterprises
Objective: We pooled the results of studies on natural history of cavernous malformations
(CM) to calculate point estimates and investigate main sources of heterogeneity. Methods …

Familial cerebral cavernous malformations

A Zafar, SA Quadri, M Farooqui, A Ikram, M Robinson… - Stroke, 2019 - Am Heart Assoc
surface interactions between these as well as with numerous binding partners. 17 FCCM is
inherited in an autosomal dominant fashion, with every affected parent having a 50 …

Cerebral cavernous malformation: what a practicing clinician should know

KD Flemming, G Lanzino - Mayo Clinic Proceedings, 2020 - Elsevier
Cavernous malformations (CMs) are angiographically occult, low-flow vascular
malformations of the central nervous system. They are acquired lesions, with approximately …

Progress in translational research on intracerebral hemorrhage: is there an end in sight?

G Xi, J Strahle, Y Hua, RF Keep - Progress in neurobiology, 2014 - Elsevier
Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which
specific therapies and treatments remain elusive. To address this, many recent experimental …

Population-based prevalence of cerebral cavernous malformations in older adults: Mayo Clinic Study of Aging

KD Flemming, J Graff-Radford, J Aakre… - JAMA …, 2017 - jamanetwork.com
Importance The prevalence of cerebral cavernous malformation (CCM) is unknown. Case
ascertainment in most previous studies was based on autopsy data or clinical convenience …

The natural history of cerebral cavernous malformations in children

BA Gross, R Du, DB Orbach, RM Scott… - Journal of Neurosurgery …, 2016 - thejns.org
OBJECT Cerebral cavernous malformations (CMs) are a source of neurological morbidity
from seizures and focal neurological deficits due to mass effect and hemorrhage. Although …

Late effects of treatment of pediatric central nervous system tumors

E Roddy, S Mueller - Journal of child neurology, 2016 - journals.sagepub.com
Central nervous system tumors represent the most common solid malignancy in childhood.
Improvement in treatment approaches have led to a significant increase in survival rates …