Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse
applications, both in medical treatments and as a staining reagent. In recent years there was …

Neuronal inclusions comprised of the microtubule-associated protein tau are found in
numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's …

Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as
neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under …

Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

Tauopathies are neurodegenerative diseases characterized by the pathological
accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary …

The failure of several Phase II/III clinical trials in Alzheimer's disease (AD) with drugs
targeting β‐amyloid accumulation in the brain fuelled an increasing interest in alternative …

Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

This report describes the behavioral and electrophysiological analysis of regulatable
transgenic mice expressing mutant repeat domains of human Tau (TauRD). Mice were …

Alzheimer's disease (AD) brains are characterized by amyloid-β-containing plaques and
hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in …