The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …

DNA methylation is an epigenetic mark that regulates multiple processes, such as gene
expression and genome stability. Mutants and pharmacological treatments have been …

The eukaryotic epigenome has an instrumental role in determining and maintaining cell
identity and function. Epigenetic components such as DNA methylation, histone tail …

The advancement in epigenetics research over the past several decades has led to the
potential application of epigenome-editing technologies for the treatment of various …

Chromatin adopts different configurations that are regulated by reversible covalent
modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for …

Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide,
causing pain, disability, and decreased quality of life. The balance between regeneration …

Background Epigenetic modifications, including DNA methylation, play an important role in
gene silencing and genome stability. Consequently, epigenetic dysregulation can cause …

Chromatin is a system of proteins and DNA that regulates chromosome organization and
gene expression in eukaryotes. Essential features that support these processes include …

DNA methylation abnormalities are regarded as critical event for cancer initiation and
development. Tumor-associated genes encompassing aberrant DNA methylation alterations …

Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …