Background The extracellular matrix (ECM) is a vital structure with a dynamic and complex
organization that plays an essential role in tissue homeostasis. In the skin, the ECM is …

The keratin cytoskeleton protects epithelia against mechanical, nonmechanical, and
physical stresses, and participates in multiple signaling pathways that regulate cell integrity …

Clustered regularly interspaced short palindromic repeat (CRISPR) has revolutionized
biomedical research by offering novel approaches to genetic and epigenetic manipulation …

Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of
mechanobullous diseases characterized by non-scarring blisters and erosions on the skin …

Dominant negative mutations in the STAT3 gene account for autosomal dominant hyper-IgE
syndrome (AD-HIES). Patients typically present high IgE serum levels, recurrent infections …

Gene editing therapies are designed to minimise off-target editing. However, it is not
widespread practice for common polymorphisms to be considered when identifying potential …

The application of allele-specific gene editing tools can expand the therapeutic options for
dominant genetic conditions, either via gene correction or via allelic gene inactivation in …

L'Epidermolyse bulleuse simplex (EBS) est une maladie cutanée principalement causée par
des mutations dominantes dans les gènes codant les kératines 5 (KRT5) ou 14 (KRT14) …

Epidermolytic ichthyosis is a hereditary skin condition caused by mutations in the KRT1 or
KRT10 genes that alter the structure of the associated keratin proteins leading to …