Y Niu, R Liu, C Guan, Y Zhang, Z Chen, S Hoerer… - Nature, 2022 - nature.com
Human sodium–glucose cotransporter 2 (hSGLT2) mediates the reabsorption of the majority of filtrated glucose in the kidney. Pharmacological inhibition of hSGLT2 by oral small …
Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC) composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator …
S Chen, L Lee, T Naila, S Fishbain, A Wang… - Nature, 2021 - nature.com
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
CRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism,–. CAST elements contain …
The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated nearly one-third of the human genome and serves as an active source of genetic diversity …
R Liu, K Song, JX Wu, XP Geng, L Zheng, X Gao… - Elife, 2022 - elifesciences.org
Phagocyte oxidase plays an essential role in the first line of host defense against pathogens. It oxidizes intracellular NADPH to reduce extracellular oxygen to produce superoxide anions …
Y Niu, W Cui, R Liu, S Wang, H Ke, X Lei… - Nature …, 2022 - nature.com
Sodium glucose co-transporters (SGLT) harness the electrochemical gradient of sodium to drive the uphill transport of glucose across the plasma membrane. Human SGLT1 (hSGLT1) …
S Chen, A Vogt, L Lee, T Naila, R McKeown… - Science …, 2023 - science.org
DNA double-strand breaks (DSBs), one of the most cytotoxic forms of DNA damage, can be repaired by the tightly regulated nonhomologous end joining (NHEJ) machinery (Stinson …
The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …