Synovial macrophages in cartilage destruction and regeneration—lessons learnt from osteoarthritis and synovial chondromatosis

Y Li, Y Zhou, Y Wang, R Crawford, Y Xiao - Biomedical Materials, 2021 - iopscience.iop.org
Inflammation is a critical process in disease pathogenesis and the restoration of tissue
structure and function, for example, in joints such as the knee and temporomandibular …

Construction of a High-Density Genetic Linkage Map and QTL Mapping for Growth-Related Traits in Takifugu bimaculatus

Y Shi, Z Zhou, B Liu, S Kong, B Chen, H Bai, L Li… - Marine …, 2020 - Springer
Takifugu bimaculatus is a euryhaline species, distributed ranging from the southern Yellow
Sea to the South China Sea. Their tolerance to a wide range of salinity and temperature …

Super-enhancer LncRNA LINC00162 promotes progression of bladder cancer

X Wang, R Zhang, S Wu, L Shen, M Ke, Y Ouyang… - Iscience, 2020 - cell.com
Due to the lack of effective early diagnostic measures and treatment methods, bladder
cancer has become a malignant tumor that seriously threatens people's lives and health …

Down-regulation of MiR-138-5p protects chondrocytes ATDC5 and CHON-001 from IL-1 β-induced inflammation via up-regulating SOX9

H Chunlei, Z Chang, L Sheng… - Current …, 2019 - ingentaconnect.com
Background: Osteoarthritis (OA) pertains to a chronic disease of degenerative joints
distinguished by articular cartilage destruction, subchondral bone remodeling, osteophyte …

Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory …

W Sun, W Wu, X Fang, X Ge, Y Zhang, J Han… - Cellular and Molecular …, 2024 - Springer
The pulmonary endothelium is a dynamic and metabolically active monolayer of endothelial
cells. Dysfunction of the pulmonary endothelial barrier plays a crucial role in the acute lung …

Reduced expression of PROX1 transitions glioblastoma cells into a mesenchymal gene expression subtype

KM Goudarzi, JA Espinoza, M Guo, J Bartek, M Nistér… - Cancer research, 2018 - AACR
The homeodomain transcription factor PROX1 has been linked to several cancer types,
including gliomas, but its functions remain to be further elucidated. Here we describe a …

SOX-9 在口腔鳞状细胞癌组织中的表达及其临床意义

刘艳玲, 赵曦, 余丽, 聂敏海 - 口腔医学研究, 2019 - manu45.magtech.com.cn
目的: 探讨SOX-9 在口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC)
中的表达及其临床意义. 方法: 采用免疫组化检测正常口腔黏膜, 口腔上皮不典型增生及口腔鳞癌 …

Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity

Z Wang, X Gao, Q Li, H Zhu, X Zhao… - Frontiers in …, 2021 - frontiersin.org
Increasing energy expenditure by promoting “browning” in adipose tissues is a promising
strategy to prevent obesity and associated diabetes. To uncover potential targets of cold …

Thrap3 promotes osteogenesis by inhibiting the degradation of Runx2

L Zhou, H Li, S Sun, T Zhang, Y Yu, L Xu… - The FASEB …, 2022 - Wiley Online Library
The dysfunction of osteogenesis is a key character in the pathogenesis of osteoporosis, but
the network of signaling mechanisms in controlling the differentiation of osteoblast remain …

THRAP3 depletion reduces PPARγ mRNA and anti-inflammatory action in 3T3-L1 adipocytes

JC Lu, CY Lu, YY Wu - Journal of Molecular Endocrinology, 2021 - jme.bioscientifica.com
Peroxisome proliferator-activated receptor γ (PPARγ) is the master transcriptional regulator
of adipocytes and the cellular target of thiazolidinedione (TZD) drugs. Suppression of pro …