Hidden codes in mRNA: Control of gene expression by m6A
S Murakami, SR Jaffrey - Molecular cell, 2022 - cell.com
Information in mRNA has largely been thought to be confined to its nucleotide sequence.
However, the advent of mapping techniques to detect modified nucleotides has revealed …
However, the advent of mapping techniques to detect modified nucleotides has revealed …
The role of m6A modification in physiology and disease
C Yang, Y Hu, B Zhou, Y Bao, Z Li, C Gong… - Cell death & …, 2020 - nature.com
Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …
Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI
C Liu, H Sun, Y Yi, W Shen, K Li, Y Xiao, F Li, Y Li… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
Abstract N 6-methyladenosine (m6A), the most abundant internal messenger RNA
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
Identification of differential RNA modifications from nanopore direct RNA sequencing with xPore
PN Pratanwanich, F Yao, Y Chen, CWQ Koh… - Nature …, 2021 - nature.com
RNA modifications, such as N 6-methyladenosine (m6A), modulate functions of cellular RNA
species. However, quantifying differences in RNA modifications has been challenging. Here …
species. However, quantifying differences in RNA modifications has been challenging. Here …
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing
Abstract N6-methyladenosine (m6A) has been increasingly recognized as a new and
important regulator of gene expression. To date, transcriptome-wide m6A detection primarily …
important regulator of gene expression. To date, transcriptome-wide m6A detection primarily …
Detection of m6A from direct RNA sequencing using a multiple instance learning framework
RNA modifications such as m6A methylation form an additional layer of complexity in the
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …