Tumor immunology and tumor evolution: intertwined histories
J Galon, D Bruni - Immunity, 2020 - cell.com
Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …
tumor and its microenvironment. Here, we review the evolution of the field of tumor …
Brain metastasis
Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Background The estimation of risk of recurrence for patients with colon carcinoma must be
improved. A robust immune score quantification is needed to introduce immune parameters …
improved. A robust immune score quantification is needed to introduce immune parameters …
Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the international …
S Hendry, R Salgado, T Gevaert… - Advances in anatomic …, 2017 - journals.lww.com
Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can
provide important prognostic information in diverse solid tumor types, and may also be of …
provide important prognostic information in diverse solid tumor types, and may also be of …
Multicenter international society for immunotherapy of cancer study of the consensus immunoscore for the prediction of survival and response to chemotherapy in …
PURPOSE The purpose of this study was to evaluate the prognostic value of Immunoscore
in patients with stage III colon cancer (CC) and to analyze its association with the effect of …
in patients with stage III colon cancer (CC) and to analyze its association with the effect of …
Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy
AJ Giles, MKND Hutchinson, HM Sonnemann… - … for immunotherapy of …, 2018 - Springer
Background Corticosteroids are routinely utilized to alleviate edema in patients with
intracranial lesions and are first-line agents to combat immune-related adverse events …
intracranial lesions and are first-line agents to combat immune-related adverse events …
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
N Priego, L Zhu, C Monteiro, M Mulders… - Nature Medicine, 2018 - nature.com
The brain microenvironment imposes a particularly intense selective pressure on metastasis-
initiating cells, but successful metastases bypass this control through mechanisms that are …
initiating cells, but successful metastases bypass this control through mechanisms that are …
[HTML][HTML] Implications of the tumor immune microenvironment for staging and therapeutics
Characterizing the tumor immune microenvironment enables the identification of new
prognostic and predictive biomarkers, the development of novel therapeutic targets and …
prognostic and predictive biomarkers, the development of novel therapeutic targets and …
Loss of XIST in breast cancer activates MSN-c-Met and reprograms microglia via exosomal miRNA to promote brain metastasis
Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet
the pathologic mechanism behind this development remains poorly understood. Here, we …
the pathologic mechanism behind this development remains poorly understood. Here, we …
[HTML][HTML] The link between the multiverse of immune microenvironments in metastases and the survival of colorectal cancer patients
M Van den Eynde, B Mlecnik, G Bindea, T Fredriksen… - Cancer cell, 2018 - cell.com
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are
homogeneous within a patient. We quantified immune cell types of 603 whole-slide …
homogeneous within a patient. We quantified immune cell types of 603 whole-slide …