Estrogen deficiency is considered to be an important factor leading to cardiovascular
diseases (CVDs). Indeed, the prevalence of CVDs in postmenopausal women exceeds that …

Cardiac contractile function is largely mediated by the regulation of Ca2+ cycling throughout
the lifespan. The sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount …

Background The novel sodium-glucose co-transporter 2 inhibitor (SGLT2i) potentially
ameliorates heart failure and reduces cardiac arrhythmia. Cardiac fibrosis plays a pivotal …

Background: Barth syndrome (BTHS) is caused by mutations of the gene encoding tafazzin,
which catalyzes maturation of mitochondrial cardiolipin and often manifests with systolic …

Background: Mutations in tafazzin (TAZ), a gene required for biogenesis of cardiolipin, the
signature phospholipid of the inner mitochondrial membrane, causes Barth syndrome …

Neuronatin (NNAT) is a transmembrane protein in the endoplasmic reticulum involved in
metabolic regulation. It shares sequence homology with sarcolipin (SLN), which negatively …

Barth syndrome (BTHS) is a rare, X-linked recessive, infantile-onset debilitating disorder
characterized by early-onset cardiomyopathy, skeletal muscle myopathy, growth delay, and …

It is well established that microgravity exposure causes significant muscle weakness and
atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss …

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …

Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental
gene due to its abundant expression in developing brains. Over the past 25 years …