Pharmacogenomics of NSAID-induced upper gastrointestinal toxicity
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used
globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary …
globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary …
Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review
M Forgerini, RC Lucchetta, G Urbano… - The …, 2021 - nature.com
Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe
adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal …
adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal …
Genetic association study and machine learning to investigate differences in platelet reactivity in patients with acute ischemic stroke treated with aspirin
A Ikonnikova, A Anisimova, S Galkin, A Gunchenko… - Biomedicines, 2022 - mdpi.com
Aspirin resistance (AR) is a pressing problem in current ischemic stroke care. Although the
role of genetic variations is widely considered, the data still remain controversial. Our aim …
role of genetic variations is widely considered, the data still remain controversial. Our aim …
Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis: A Secondary Analysis of a Randomized Clinical Trial
Importance Eicosanoids have a pathophysiological role in atopic dermatitis (AD), but it is
unknown whether this is affected by prenatal ω-3 long-chain polyunsaturated fatty acid (n-3 …
unknown whether this is affected by prenatal ω-3 long-chain polyunsaturated fatty acid (n-3 …
[HTML][HTML] The role of CYP2C9*2, CYP2C9*3 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study
M Forgerini, G Urbano, TR De Nadai… - … of Pharmacy & …, 2023 - frontierspartnerships.org
Purpose: To investigate whether interindividual variability in the CYP2C9 (* 2 and* 3 alleles)
and VKORC1 (rs9923231) genes is associated with increased risk of upper gastrointestinal …
and VKORC1 (rs9923231) genes is associated with increased risk of upper gastrointestinal …
Clinically relevant endothelial nitric oxide synthase polymorphisms and their impact on drug response
CK Cotta Filho, GH Oliveira-Paula… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Nitric oxide (NO) is a molecule with multiple functions. Several drugs involve the
modulation of NO levels in their mechanism of action. NO is mainly produced in vessels by …
modulation of NO levels in their mechanism of action. NO is mainly produced in vessels by …
Epidemiological profile of patients with non-variceal upper gastrointestinal bleeding secondary to peptic disease in a tertiary referral Brazilian hospital
M Forgerini, G Urbano, TRD Nadai… - Arquivos de …, 2021 - SciELO Brasil
ABSTRACT BACKGROUND: Non-variceal upper gastrointestinal bleeding (NVUGIB)
secondary to peptic ulcer disease is a medical digestive emergency and could be one of the …
secondary to peptic ulcer disease is a medical digestive emergency and could be one of the …
The Impact of TBXA2R Gene Variants on the Risk of Aspirin-Induced Upper Gastrointestinal Bleeding: A Case-Control Study
Objective: Upper gastrointestinal bleeding (UGIB) has been identified as a potential adverse
drug reaction associated with the use of low-dose aspirin (LDA). This study aimed to …
drug reaction associated with the use of low-dose aspirin (LDA). This study aimed to …
Use of antidepressants and the risk of upper gastrointestinal tract bleeding: a case-control study
Purpose To investigate the association between the use of antidepressants and the risk of
upper gastrointestinal tract bleeding (UGIB). Methods A Case-control study was conducted …
upper gastrointestinal tract bleeding (UGIB). Methods A Case-control study was conducted …
Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control …
N Mallah, M Zapata-Cachafeiro, C Aguirre… - Annals of …, 2022 - Taylor & Francis
Background Interindividual genetic variations contribute to differences in patients' response
to drugs as well as to the development of certain disorders. Patients who use non-steroidal …
to drugs as well as to the development of certain disorders. Patients who use non-steroidal …