Current advances on structure-function relationships of pyridoxal 5′-phosphate-dependent enzymes
Pyridoxal 5′-phosphate (PLP) functions as a coenzyme in many enzymatic processes,
including decarboxylation, deamination, transamination, racemization, and others. Enzymes …
including decarboxylation, deamination, transamination, racemization, and others. Enzymes …
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
RS Jansen, L Mandyoli, R Hughes… - Nature …, 2020 - nature.com
Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a
putative pyridoxal phosphate-binding protein of unknown function. Here we use …
putative pyridoxal phosphate-binding protein of unknown function. Here we use …
Cyclipostins and Cyclophostin Analogues as Multitarget Inhibitors That Impair Growth of Mycobacterium abscessus
A Madani, JN Ridenour, BP Martin… - ACS infectious …, 2019 - ACS Publications
Twelve new Cyclophostin and Cyclipostins analogues (CyC 19–30) were synthesized, thus
extending our series to 38 CyCs. Their antibacterial activities were evaluated against four …
extending our series to 38 CyCs. Their antibacterial activities were evaluated against four …
Multisubstrate specificity shaped the complex evolution of the aminotransferase family across the tree of life
Aminotransferases (ATs) are an ancient enzyme family that play central roles in core
nitrogen metabolism, essential to all organisms. However, many of the AT enzyme functions …
nitrogen metabolism, essential to all organisms. However, many of the AT enzyme functions …
[HTML][HTML] Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6)
M Rutkiewicz, I Nogues, W Witek, S Angelaccio… - Plant Physiology and …, 2023 - Elsevier
Histidinol-phosphate aminotransferase is the sixth protein (hence HISN6) in the histidine
biosynthetic pathway in plants. HISN6 is a pyridoxal 5′-phosphate (PLP)-dependent …
biosynthetic pathway in plants. HISN6 is a pyridoxal 5′-phosphate (PLP)-dependent …
Repurposed HisC aminotransferases complete the biosynthesis of some methanobactins
Methanobactins (Mbns) are ribosomally produced, post-translationally modified bacterial
natural products with a high affinity for copper. MbnN, a pyridoxal 5′-phosphate-dependent …
natural products with a high affinity for copper. MbnN, a pyridoxal 5′-phosphate-dependent …
Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol‐phosphate dehydratase
D Kumar, B Jha, I Bhatia, A Ashraf… - Proteins: Structure …, 2022 - Wiley Online Library
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), employs
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …
[HTML][HTML] In silico identification and characterization of promising drug targets in highly virulent uropathogenic Escherichia coli strain CFT073 by protein-protein …
Urinary tract infections (UTIs) are one of the commonest bacterial infections worldwide. The
most common etiological agent is uropathogenic Escherichia coli. The occurrence of high …
most common etiological agent is uropathogenic Escherichia coli. The occurrence of high …
Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense
Nitrogen metabolism of M. tuberculosis is critical for its survival in infected host cells. M.
tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and …
tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and …
Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis
The absence of a histidine biosynthesis pathway in humans, coupled with histidine
essentiality for survival of the important human pathogen Mycobacterium tuberculosis (Mtb) …
essentiality for survival of the important human pathogen Mycobacterium tuberculosis (Mtb) …