Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases

J Xu, Y Song, S Ding, W Duan, G Xiang… - Cytokine & Growth Factor …, 2024 - Elsevier
Myeloid-derived growth factor (MYDGF) is a paracrine protein produced by bone marrow-
derived monocytes and macrophages. Current research shows that it has protective effects …

Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice

L Shi, Y Li, X Xu, Y Cheng, B Meng, J Xu, L Xiang… - Nature …, 2022 - nature.com
Brown adipose tissue (BAT) activity contributes to cardiovascular health by its energy-
dissipating capacity but how BAT modulates vascular function and atherosclerosis through …

Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKβ/NF-κB signaling

Y Ding, X Xu, B Meng, L Wang, B Zhu, B Guo… - Cell Death & …, 2023 - nature.com
Whether bone marrow modulates systemic metabolism remains unknown. Our recent study
suggested that myeloid-derived growth factor (MYDGF) improves insulin resistance. Here …

Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice

B Meng, Y Li, Y Ding, X Xu, L Wang, B Guo, B Zhu… - Science …, 2021 - science.org
Whether bone marrow modulates systemic metabolism remains unknown. Here, we found
that (i) myeloid cell–specific myeloid-derived growth factor (MYDGF) deficiency exacerbated …

Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease

P Zhan, Y Zhang, W Shi, X Liu, Z Qiao, Z Wang… - Kidney International, 2022 - Elsevier
Podocytes are unique, highly specialized, terminally differentiated cells, which are restricted
in a post-mitotic state with limited ability to repair or regenerate. Re-entering the mitotic …

Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes

L Große-Segerath, P Follert, K Behnke, J Ettich… - Nature …, 2024 - nature.com
Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …

MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease

M He, Y Li, L Wang, B Guo, W Mei, B Zhu, J Zhang… - Diabetologia, 2020 - Springer
Aims/hypothesis Myeloid-derived growth factor (MYDGF), mainly secreted by bone marrow-
derived cells, has been known to promote glucagon-like peptide-1 production and improve …

Protective role of small extracellular vesicles derived from HUVECs treated with AGEs in diabetic vascular calcification

B Guo, SK Shan, F Xu, X Lin, FX Li, Y Wang… - Journal of …, 2022 - Springer
The pathogenesis of vascular calcification in diabetic patients remains elusive. As an
effective information transmitter, small extracellular vesicles (sEVs) carry abundant …

Inflammatory cell–derived MYDGF attenuates endothelial LDL transcytosis to protect against atherogenesis

J Xu, H Ma, L Shi, H Zhou, Y Cheng… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: Inflammation contributes to the pathogenesis of atherosclerosis. But little is
known about the potential benefits of inflammatory cells to atherosclerosis. The aim of this …

Myeloid-derived growth factor in diseases: structure, function and mechanisms

P Chen, X Huang, W Li, W Wen, Y Cao, J Li… - Molecular …, 2024 - Springer
Myeloid-derived growth factor (MYDGF) is a novel secreted protein with potent antiapoptotic
and tissue-repairing properties that is present in nearly 140 human tissues and cell lines …