Decoding the role of miRNAs in multiple myeloma pathogenesis: a focus on signaling pathways

AM Yehia, EGE Elsakka, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy

S Trino, D Lamorte, A Caivano, L De Luca, A Sgambato… - Leukemia, 2021 - nature.com
In the era of precision medicine, liquid biopsy is becoming increasingly important in
oncology. It consists in the isolation and analysis of tumor-derived biomarkers, including …

MiR-129-5p shuttled by human synovial mesenchymal stem cell-derived exosomes relieves IL-1β induced osteoarthritis via targeting HMGB1

M Qiu, D Liu, Q Fu - Life Sciences, 2021 - Elsevier
Aims To explore the therapeutic effect of miR-129-5p carried by exosomes from Human
Synovial Mesenchymal Stem Cell (HS-MSC) on osteoarthritis (OA). Materials and methods …

Plant-RNA in extracellular vesicles: the secret of cross-kingdom communication

O Urzì, R Gasparro, NR Ganji, R Alessandro… - Membranes, 2022 - mdpi.com
The release of extracellular vesicles (EVs) is a common language, used by living organisms
from different kingdoms as a means of communication between them. Extracellular vesicles …

Tumor-derived small extracellular vesicles induce pro-inflammatory cytokine expression and PD-L1 regulation in M0 macrophages via IL-6/STAT3 and TLR4 signaling …

M Pucci, S Raimondo, O Urzì, M Moschetti… - International Journal of …, 2021 - mdpi.com
Tumor-associated macrophages play a key role in promoting tumor progression by exerting
an immunosuppressive phenotype associated with the expression of programmed cell death …

Bone marrow mesenchymal stromal cells in multiple myeloma: Their role as active contributors to myeloma progression

P Maiso, P Mogollón, EM Ocio, M Garayoa - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma is a cancer of immunoglobulin-secreting cells that
accumulate in the bone marrow. Mesenchymal stromal cells are important components of …

Overcoming the immunosuppressive tumor microenvironment in multiple myeloma

FM Uckun - Cancers, 2021 - mdpi.com
Simple Summary This article provides a comprehensive review of new and emerging
treatment strategies against multiple myeloma that employ precision medicines and/or drugs …

Myeloma bone disease: a comprehensive review

SKR Mukkamalla, D Malipeddi - International journal of molecular …, 2021 - mdpi.com
Multiple myeloma (MM) is a neoplastic clonal proliferation of plasma cells in the bone
marrow microenvironment, characterized by overproduction of heavy-and light-chain …

[HTML][HTML] Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression

D García-Sánchez, A González-González… - World Journal of Stem …, 2023 - ncbi.nlm.nih.gov
Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of
immunoglobulin-secreting clonal plasma cells at the bone marrow (BM). The interaction …

Drug resistance in multiple myeloma: Soldiers and weapons in the bone marrow niche

AG Solimando, E Malerba, P Leone, M Prete… - Frontiers in …, 2022 - frontiersin.org
Multiple myeloma (MM) is still an incurable disease, despite considerable improvements in
treatment strategies, as resistance to most currently available agents is not uncommon. In …