Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …

The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Cholangiocarcinoma represents a diverse group of epithelial cancers united by late
diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are …

Anthraquinones are privileged chemical scaffolds that have been used for centuries in
various therapeutic applications. The anthraquinone moiety forms the core of various …

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …

Human cancers share properties referred to as hallmarks, among which sustained
proliferation, escape from apoptosis, and genomic instability are the most pervasive. The …