Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

Skeletal muscle is the most abundant type of tissue in human body, being involved in
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …

Abstract B-cell lymphoma 2 (BCL2) proteins are important cell death regulators, whose main
function is to control the release of cytochrome c from mitochondria in the intrinsic apoptotic …

Autophagy and apoptosis are crucial cellular housekeeping and tissue survival
mechanisms. There is emerging evidence of important crosstalk between apoptosis and …

The fate of a cell is determined by multiple signaling pathways in response to a range of
stimuli. Probably the most prominent cell death mechanism is apoptosis which can be …

Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity
and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking …

The significance of IL-6 production in tuberculosis is yet to be fully elucidated, although it is
known for quite some time that IL-6 interferes with IFN-γ induced signal. In order to know …

The Bcl-2 family members rigorously regulate cell endogenous apoptosis, and targeting anti-
apoptotic members is a hot topic in design of anti-cancer drugs. At present, FDA and EMA …

RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process.
Since its discovery, tremendous efforts have been made to translate RNAi technology into …