The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Metallodrugs offer potential for unique mechanism of drug action based on the choice of the
metal, its oxidation state, the types and number of coordinated ligands and the coordination …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

Of the new generation platinum compounds that have been evaluated, those with the 1, 2-
diaminocyclohexane carrier ligand–including oxaliplatin–have been focused upon in recent …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …

Cellular DNA is susceptible to chemical modifications when exposed to various
environmental agents, chemotherapeutic agents, or endogenous agents produced by …

Thirty years after the onset of the first clinical studies with cisplatin, the development of
antineoplastic platinum drugs continues to be a productive field of research. This article …

Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA
and forms 1, 2-d (ApG), 1, 2-d (GpG) and 1, 3-d (GpTpG) intrastrand crosslinks, interstrand …