Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Digital immunoassays with multiplexed capacity, ultrahigh sensitivity, and broad affordability
are urgently required in clinical diagnosis, food safety, and environmental monitoring. In this …

Fluctuations in the systemic concentration levels of metabolites, nutritionally relevant peptide
hormones, protein biomarkers, and therapeutic materials provide a wealth of information that …

With recent advances in point-of-care testing, wearable electronics, and implantable medical
devices, there is a growing interest in developing state-of-the-art methods to monitor human …

Phase separation and percolation contribute to phase transitions of multivalent
macromolecules. Contributions of percolation are evident through the viscoelasticity of …

Misfolded protein oligomers are of central importance in both the diagnosis and treatment of
Alzheimer's and Parkinson's diseases. However, accurate high-throughput methods to …

Oligomeric species arising during the aggregation of α-synuclein are implicated as a major
source of toxicity in Parkinson's disease, and thus a major potential drug target. However …

Live-cell imaging is a powerful technique to study the dynamics and mechanics of various
biological molecules like proteins, organelles, DNA, and RNA. With the rapid evolution of …

The physical characterization of proteins in terms of their sizes, interactions, and assembly
states is key to understanding their biological function and dysfunction. However, this has …

Supramolecular chemistry is a relatively new field of study that utilizes conventional
chemical knowledge to produce new edges of smart materials. One such material use of …