The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Abstract System xc− contributes to glutathione (GSH) synthesis and protects cells against
ferroptosis by importing cystine and exchanging it with glutamate. Transforming growth …

The transforming growth factor-beta (TGF-!) belongs to a superfamily of cytokines that act on
protein kinase receptors at the plasma membrane to induce a plethora of biological signals …

Simple Summary Transforming Growth Factor-beta (TGF-β) signaling is crucial to maintain
tissue homeostasis. Alterations in TGF-β signaling impact tissue functions and favor the …

The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an
epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and …

Objective—Marfan's syndrome is characterized by the formation of ascending aortic
aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic …

The multikinase inhibitor sorafenib is the only effective drug in advanced cases of
hepatocellular carcinoma (HCC). However, response differs among patients and …

As cellular models for in vitro liver cancer and toxicity studies, HepG2 and Hep3B are the
two most frequently used liver cancer cell lines. Because of their similarities they are often …

Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality.
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …