Translating results from pre-clinical animal studies to successful human clinical trials in
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …

Parkinson's disease (PD) is associated with a large burden of non-motor symptoms
including olfactory and autonomic dysfunction, as well as neuropsychiatric (depression …

In long-term spaceflight, astronauts will face unique cognitive loads and social challenges
which will be complicated by communication delays with Earth. It is important to understand …

Reliable and reproducible assessment of animal learning and behavior is a central aim of
basic and translational neuroscience research. Recent developments in automated operant …

Lesions of the dorsomedial striatum elicit deficits in cognitive flexibility that are an early
feature of Parkinson's disease (PD), and presumably reflect alterations in frontostriatal …

Significant evidence suggests that misfolded alpha‐synuclein (aSyn), a major component of
Lewy bodies, propagates in a prion‐like manner contributing to disease progression in …

Recent studies in our labs have implicated a role for glial cells (astrocytes and microglia) in
exercise-induced synaptogenesis and synaptic repair. The primary goal of this application is …

Lesions of the dorsomedial striatum elicit deficits in cognitive flexibility that are an early
feature of Parkinson's disease (PD), and presumably reflect alterations in frontostriatal …

Zebra finches are a well-established animal model for probing the molecular and
neuroanatomical mechanisms underlying several forms of learning. Much of the past …

Recent studies in our labs have implicated a role for glial cells (astrocytes and microglia) in
exerciseinduced synaptogenesis and synaptic repair. The primary goal of this application is …