Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …

The importance of the modulation of pain by emotion is now widely recognised. In particular,
stress and anxiety, depending on their nature, duration and intensity, can exert potent, but …

The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …

Characterised by chronic widespread musculoskeletal pain, generalised hyperalgesia, and
psychological distress, fibromyalgia (FM) is a significant unmet clinical need. The …

Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …

BACKGROUND & AIMS: Stress alters brain–gut interactions and could exacerbate intestinal
disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have …

Background & Aims Chronic stress alters the hypothalamic–pituitary–adrenal axis, increases
gut motility, and increases the perception of visceral pain. We investigated whether …

The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed
throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are …

The elucidation of Δ 9-tetrahydrocannabinol as the active principal of Cannabis sativa in
1963 initiated a fruitful half-century of scientific discovery, culminating in the identification of …