Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

In biology, it can be argued that if the genome contains the script for a cell's life cycle, then
the proteome constitutes an ensemble cast of actors that brings these instructions to life …

As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large
conformational space. Certain conformations lead to aggregation prone and non …

With the recognition of the importance of the gut–brain axis in Parkinson's disease (PD)
etiology, there is increased interest in developing therapeutic strategies that target α …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

Cytosolic protein delivery is of great importance for basic cell biology and the discovery of
novel protein-based biotherapeutics. It remains a challenging task because of the limited …

In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have
emerged as two of the most useful methods in mass spectrometry‐based protein analysis …

Abstract α-Synuclein is an intrinsically disordered protein that can self-aggregate and plays
a major role in Parkinson's disease (PD). Elevated levels of certain metal ions are found in …

Highlights•A range of functionally and structurally unrelated proteins form amyloid.•Toxic
intermediates remain elusive, making their targeting a significant challenge.•Design and …

The solvation shell is essential for the folding and function of proteins, but how it contributes
to protein misfolding and aggregation has still to be elucidated. We show that the mobility of …