From spheroids to organoids: the next generation of model systems of human cardiac regeneration in a dish
Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …
the differentiation of stem cells. The growing interest in the use of organoids arises from their …
Myocardial regeneration protocols towards the routine clinical scenario: An unseemly path from bench to bedside
Heart failure secondary to cardiomyocyte loss and/or dysfunction is the number one killer
worldwide. The field of myocardial regeneration with its far-reaching primary goal of cardiac …
worldwide. The field of myocardial regeneration with its far-reaching primary goal of cardiac …
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice
Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …
Unraveling and targeting myocardial regeneration deficit in diabetes
Cardiomyopathy is a common complication in diabetic patients. Ventricular dysfunction
without coronary atherosclerosis and hypertension is driven by hyperglycemia …
without coronary atherosclerosis and hypertension is driven by hyperglycemia …
Diabetes-induced cellular senescence and senescence-associated secretory phenotype impair cardiac regeneration and function independently of age
Diabetes mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells
(CSCs) and adult myocardial regeneration. We assessed the hypothesis that senescence …
(CSCs) and adult myocardial regeneration. We assessed the hypothesis that senescence …
Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification
Background: Three-dimensional cell culture systems hold great promise for bridging the gap
between in vitro cell-based model systems and small animal models to study tissue biology …
between in vitro cell-based model systems and small animal models to study tissue biology …
Streptozotocin-induced type 1 and 2 diabetes mellitus mouse models show different functional, cellular and molecular patterns of diabetic cardiomyopathy
The main cause of morbidity and mortality in diabetes mellitus (DM) is cardiovascular
complications. Diabetic cardiomyopathy (DCM) remains incompletely understood. Animal …
complications. Diabetic cardiomyopathy (DCM) remains incompletely understood. Animal …
Polarizing macrophage functional phenotype to foster cardiac regeneration
There is an increasing interest in understanding the connection between the immune and
cardiovascular systems, which are highly integrated and communicate through finely …
cardiovascular systems, which are highly integrated and communicate through finely …
Stem Cell‐Based Therapy and Cell‐Free Therapy as an Alternative Approach for Cardiac Regeneration
I Deszcz - Stem Cells International, 2023 - Wiley Online Library
The World Health Organization reports that cardiovascular diseases (CVDs) represent 32%
of all global deaths. The ineffectiveness of conventional therapies in CVDs encourages the …
of all global deaths. The ineffectiveness of conventional therapies in CVDs encourages the …
[HTML][HTML] Cardiac stem cells: Current knowledge and future prospects
RA Mehanna, MM Essawy, MA Barkat… - World journal of stem …, 2022 - ncbi.nlm.nih.gov
Regenerative medicine is the field concerned with the repair and restoration of the integrity
of damaged human tissues as well as whole organs. Since the inception of the field several …
of damaged human tissues as well as whole organs. Since the inception of the field several …