Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect
Z Zhao, X Dai, C Li, X Wang, J Tian, Y Feng… - European journal of …, 2020 - Elsevier
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …
Biological aspects of Schiff base–metal complexes derived from benzaldehydes: an overview
RK Mohapatra, PK Das, MK Pradhan… - Journal of the Iranian …, 2018 - Springer
Schiff bases are stable imines containing C= N, where N is bonded to an alkyl or aryl group,
but not with hydrogen and are prepared by condensation of aliphatic or aromatic primary …
but not with hydrogen and are prepared by condensation of aliphatic or aromatic primary …
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
2ʹ-Aryl and 4ʹ-arylidene substituted pyrazolones: As potential α-amylase inhibitors
Acarbose and voglibose are well-known α-amylase inhibitors used for the management of
type-II diabetes mellitus. Unfortunately, these well-known and clinically used inhibitors are …
type-II diabetes mellitus. Unfortunately, these well-known and clinically used inhibitors are …
Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides
This research introduces a series of fourteen 4-aryl-hydrazonopyrazolone sulfonamide
derivatives, denoted as 3 (ag) and 4 (ag), which encompass various aromatic substitutions …
derivatives, denoted as 3 (ag) and 4 (ag), which encompass various aromatic substitutions …
Indole-3-acetamides: As potential antihyperglycemic and antioxidant agents; synthesis, in vitro α-amylase inhibitory activity, structure–activity relationship, and in silico …
Kanwal, KM Khan, S Chigurupati, F Ali, M Younus… - ACS …, 2021 - ACS Publications
Indole-3-acetamides (1–24) were synthesized via coupling of indole-3-acetic acid with
various substituted anilines in the presence of coupling reagent 1, 1-carbonyldiimidazole …
various substituted anilines in the presence of coupling reagent 1, 1-carbonyldiimidazole …
Substituted benzimidazole analogues as potential α-amylase inhibitors and radical scavengers
Benzimidazole scaffolds are known to have a diverse range of biological activities and found
to be antidiabetic and antioxidant. In this study, a variety of arylated benzimidazoles 1–31 …
to be antidiabetic and antioxidant. In this study, a variety of arylated benzimidazoles 1–31 …
Biology-oriented synthesis (BIOS) of piperine derivatives and their comparative analgesic and antiinflammatory activities
Background: Serious side effects such as gastric intestinal ulcer, bleeding etc. are
associated with most of the antiinflammatory and analgesic drugs. So, there is a need to …
associated with most of the antiinflammatory and analgesic drugs. So, there is a need to …
Evaluation of S-substituted-2-mercaptobenzimidazole analogs for urease inhibitory and DPPH radical scavenging potential: synthesis, bioactivity, and molecular …
Abstract Several S-substituted-2-mercaptobenzimidazole derivatives 1–34 were synthesized
by reacting 2-mercaptobenzimidazole with a variety of substituted benzyl bromide and …
by reacting 2-mercaptobenzimidazole with a variety of substituted benzyl bromide and …
[PDF][PDF] Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors
Aromatic/heterocyclic Schiff bases are one of the most investigated and studied scaffold for
many pharmaceutical applications. For this reason, in the current work, a series of aromatic …
many pharmaceutical applications. For this reason, in the current work, a series of aromatic …