Autosomal recessive primary microcephaly (MCPH;“small head syndrome”) is a rare,
heterogeneous disease arising from the decreased production of neurons during brain …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

The primary cilium, a microtubule based organelle protruding from the cell surface and
acting as an antenna in multiple signaling pathways, takes center stage in the formation of …

During mammalian brain development, neural stem and progenitor cells generate the
neurons for the six-layered neocortex. The proliferative capacity of the different types of …

The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary
cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types …

Dynamic assembly and disassembly of primary cilia controls embryonic development and
tissue homeostasis. Dysregulation of ciliogenesis causes human developmental diseases …

A subset of genetic disorders termed ciliopathies are associated with obesity. The
mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes …

Mutations in centrosome genes deplete neural progenitor cells (NPCs) during brain
development, causing microcephaly. While NPC attrition is linked to TP53‐mediated cell …

Corticogenesis is an intricate process controlled temporally and spatially by many intrinsic
and extrinsic factors. Alterations during this important process can lead to severe cortical …

WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are
causative for human microcephaly, indicating critical roles in cell expansion required for …