Hsp70 proteins are central components of the cellular network of molecular chaperones and
folding catalysts. They assist a large variety of protein folding processes in the cell by …

To dampen proteotoxic stresses and maintain protein homeostasis, organisms possess a
stress-responsive molecular machinery that detects and neutralizes protein damage. A …

Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Age-related macular degeneration is the principal cause of registered legal blindness
among those aged over 65 in the United States, western Europe, Australia, and Japan …

Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

Summary Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in
eukaryotes, a very highly conserved protective mechanism. HSF1 function increases …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are …

This review discusses the structure and function of molecular chaperones, with emphasis on
their role in rescuing misfolded proteins. It also includes a discussion of the diseases in …

Ageing, a basic biological process seen in all living creatures, is not preventable. Surgical
and topical modalities have been invented and substances were applied topically to alter …

Chronic photodamage of the skin manifests itself as extrinsic skin ageing (photoageing) and
photocarcinogenesis. DNA photodamage and UV‐generated reactive oxygen species are …