Physiology and role of irisin in glucose homeostasis

N Perakakis, GA Triantafyllou… - Nature reviews …, 2017 - nature.com
Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Role of irisin in myocardial infarction, heart failure, and cardiac hypertrophy

MY Ho, CY Wang - Cells, 2021 - mdpi.com
Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin
regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning …

Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process

H Zhang, X Wu, J Liang, M Kirberger, N Chen - Ageing research reviews, 2022 - Elsevier
Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple tissues
and organs, and exercise and cold exposure are the major inducers for its secretion. Irisin …

A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: an introductory review

H Askari, SF Rajani, M Poorebrahim… - Pharmacological …, 2018 - Elsevier
Irisin is a hormone-like molecule mainly released by skeletal muscles in response to
exercise. Irisin induces browning of the white adipose tissue and has been shown to …

Myokines and heart failure: challenging role in adverse cardiac remodeling, myopathy, and clinical outcomes

AE Berezin, AA Berezin, M Lichtenauer - Disease Markers, 2021 - Wiley Online Library
Heart failure (HF) is a global medical problem that characterizes poor prognosis and high
economic burden for the health system and family of the HF patients. Although modern …

Protective effect of irisin on atherosclerosis via suppressing oxidized low density lipoprotein induced vascular inflammation and endothelial dysfunction

Y Zhang, Q Mu, Z Zhou, H Song, Y Zhang, F Wu… - PloS one, 2016 - journals.plos.org
Irisin, a newly discovered myokine, is considered as a promising candidate for the treatment
of metabolic disturbances and cardiovascular diseases. In the present study, we used two …

Irisin a novel metabolic biomarker: present knowledge and future directions

IY Martinez Munoz… - International journal …, 2018 - Wiley Online Library
The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular
diseases owing to fat mass excess has been described. In recent years, muscle …

Irisin inhibits hepatic cholesterol synthesis via AMPK-SREBP2 signaling

H Tang, R Yu, S Liu, B Huwatibieke, Z Li, W Zhang - EBioMedicine, 2016 - thelancet.com
Irisin, a myokine released during exercise, promotes browning of subcutaneous adipose
tissue and regulates energy homeostasis. Although exercise constantly reduces blood …

[HTML][HTML] A review on the role of irisin in insulin resistance and type 2 diabetes mellitus

M Gizaw, P Anandakumar, T Debela - Journal of …, 2017 - ncbi.nlm.nih.gov
Irisin is a novel hormone like polypeptide that is cleaved and secreted by an unknown
protease from fibronectin type III domain-containing protein 5 (FNDC5), a membrane …

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

C Xie, Y Zhang, TDN Tran, H Wang, S Li, EV George… - PloS one, 2015 - journals.plos.org
Exercise offers short-term and long-term health benefits, including an increased metabolic
rate and energy expenditure in myocardium. The newly-discovered exercise-induced …